Article
The active conformation of plasminogen activator inhibitor 1, a target for drugs to control fibrinolysis and cell adhesion.
Structure (London, England : 1993) - 15 Feb 1999
Sharp A M, Stein P E, Pannu N S, Carrell R W, Berkenpas M B, Ginsburg D, Lawrence D A, Read R J
Abstract excerpt
BACKGROUND: Plasminogen activator inhibitor 1 (PAI-1) is a serpin that has a key role in the control of fibrinolysis through proteinase inhibition. PAI-1 also has a role in regulating cell adhesion processes relevant to tissue remodeling and metastasis; this role is mediated by its binding to the adhesive glycoprotein vitronectin rather than by proteinase inhibition. Active PAI-1 is metastable and spontaneously...
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