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Article

Topological layers in the HIV-1 gp120 inner domain regulate gp41 interaction and CD4-triggered conformational transitions.

Molecular cell - 12 Mar 2010

Finzi Andrés, Xiang Shi-Hua, Pacheco Beatriz, Wang Liping, Haight Jessica, Kassa Aemro, Danek Brenda, Pancera Marie, Kwong Peter D, Sodroski Joseph

Abstract excerpt

The entry of human immunodeficiency virus (HIV-1) into cells is initiated by binding of the gp120 exterior envelope glycoprotein to the receptor, CD4. How does CD4 binding trigger conformational changes in gp120 that allow the gp41 transmembrane envelope glycoprotein to mediate viral-cell membrane fusion? The transition from the unliganded to the CD4-bound state is regulated by two potentially flexible...

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Share to CD4 Antigens
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20227370
DOI: 10.1016/j.molcel.2010.02.012
PMCID: PMC2854584

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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