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Article

The highly conserved layer-3 component of the HIV-1 gp120 inner domain is critical for CD4-required conformational transitions.

Journal of virology - 1 Mar 2013

Désormeaux Anik, Coutu Mathieu, Medjahed Halima, Pacheco Beatriz, Herschhorn Alon, Gu Christopher, Xiang Shi-Hua, Mao Youdong, Sodroski Joseph, Finzi Andrés

Abstract excerpt

The trimeric envelope glycoprotein (Env) of human immunodeficiency virus type 1 (HIV-1) mediates virus entry into host cells. CD4 engagement with the gp120 exterior envelope glycoprotein subunit represents the first step during HIV-1 entry. CD4-induced conformational changes in the gp120 inner domain involve three potentially flexible topological layers (layers 1, 2, and 3). Structural rearrangements between...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23255784
DOI: 10.1128/JVI.03104-12
PMCID: PMC3571356

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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