Interhelical Interactions in the gp41 Core:  Implications for Activation of HIV-1 Membrane Fusion<sup>,</sup>

doi:10.1021/bi025648y

Article

Interhelical Interactions in the gp41 Core: Implications for Activation of HIV-1 Membrane Fusion<sup>,</sup>

10 May 2002

Abstract excerpt

The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein complex (gp120-gp41) promotes viral entry by mediating the fusion of viral and cellular membranes. Formation of a stable trimer-of-hairpins structure in the gp41 ectodomain brings the two membranes into proximity, leading to membrane fusion. The core of this hairpin structure is a six-helix bundle in which three carboxyl-terminal outer helices...

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