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Article

Stabilizing exposure of conserved epitopes by structure guided insertion of disulfide bond in HIV-1 envelope glycoprotein.

PloS one - 1 Jan 2013

Kassa Aemro, Dey Antu K, Sarkar Pampi, Labranche Celia, Go Eden P, Clark Daniel F, Sun Yide, Nandi Avishek, Hartog Karin, Desaire Heather, Montefiori David, Carfi Andrea, Srivastava Indresh K, Barnett Susan W

Abstract excerpt

Entry of HIV-1 into target cells requires binding of the viral envelope glycoprotein (Env) to cellular receptors and subsequent conformational changes that culminates in fusion of viral and target cell membranes. Recent structural information has revealed that these conformational transitions are regulated by three conserved but potentially flexible layers stacked between the receptor-binding domain (gp120) and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to env Gene Products, Human Immunodeficiency Virus

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PMID: 24146829
DOI: 10.1371/journal.pone.0076139
PMCID: PMC3797752

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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