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Article

PP2A T61 epsilon is an inhibitor of MAP4K3 in nutrient signaling to mTOR.

Molecular cell - 12 Mar 2010

Yan Lijun, Mieulet Virginie, Burgess Darren, Findlay Greg M, Sully Katherine, Procter Julia, Goris Jozef, Janssens Veerle, Morrice Nick A, Lamb Richard F

Abstract excerpt

The mammalian target of rapamycin (mTOR) pathway is activated by a variety of stimuli, including nutrients such as glucose and amino acids. The Ste20 family kinase MAP4K3 is regulated by amino acids and acts upstream of mTORC1. Here we investigate how MAP4K3 activity is regulated by amino acid sufficiency. We identify a transautophosphorylation site in the MAP4K3 kinase activation segment (Ser170) that is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20227368
DOI: 10.1016/j.molcel.2010.01.031

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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