Article
ErbB activity links the glucagon-like peptide-2 receptor to refeeding-induced adaptation in the murine small bowel.
Gastroenterology - 1 Jun 2010
Bahrami Jasmine, Yusta Bernardo, Drucker Daniel J
Abstract excerpt
BACKGROUND & AIMS: The small bowel mucosa is sensitive to nutrients and undergoes rapid adaptation to nutrient deprivation and refeeding through changes in apoptosis and cell proliferation, respectively. Although glucagon-like peptide-2 (GLP-2) exerts trophic effects on the gut and levels increase with refeeding, mechanisms linking GLP-2 to mucosal adaptation to refeeding remain unclear. METHODS: Fasting and...
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