Article
Mutations of pvdhfr and pvdhps genes in vivax endemic-malaria areas in Kota Marudu and Kalabakan, Sabah.
Malaria journal - 5 Feb 2016
Sastu Umi Rubiah, Abdullah Noor Rain, Norahmad Nor Azrina, Saat Muhammad Nor Farhan, Muniandy Prem Kumar, Jelip Jenarun, Tikuson Moizin, Yusof Norsalleh, Sidek Hasidah Mohd
Abstract excerpt
BACKGROUND: Malaria cases persist in some remote areas in Sabah and Sarawak despite the ongoing and largely successful malaria control programme conducted by the Vector Borne Disease Control Programme, Ministry Of Health, Malaysia. Point mutations in the genes that encode the two enzymes involved in the folate biosynthesis pathway, dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) enzymes confer...
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