Article
LIMD1 is more frequently altered than RB1 in head and neck squamous cell carcinoma: clinical and prognostic implications.
Molecular cancer - 12 Mar 2010
Ghosh Susmita, Ghosh Amlan, Maiti Guru P, Mukherjee Nupur, Dutta Sankhadeep, Roy Anup, Roychoudhury Susanta, Panda Chinmay K
Abstract excerpt
INTRODUCTION: To understand the role of two interacting proteins LIMD1 and pRB in development of head and neck squamous cell carcinoma (HNSCC), alterations of these genes were analyzed in 25 dysplastic head and neck lesions, 58 primary HNSCC samples and two HNSCC cell lines. METHODS: Deletions of LIMD1 and RB1 were analyzed along with mutation and promoter methylation analysis of LIMD1. The genotyping of LIMD1...
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