Article
Alterations of 3p21.31 tumor suppressor genes in head and neck squamous cell carcinoma: Correlation with progression and prognosis.
International journal of cancer - 1 Dec 2008
Ghosh Susmita, Ghosh Amlan, Maiti Guru Prasad, Alam Neyaz, Roy Anup, Roy Bidyut, Roychoudhury Susanta, Panda Chinmay Kumar
Abstract excerpt
The aim of our study was to analyze the alterations of some candidate tumor suppressor genes (TSGs) viz. LIMD1, LTF, CDC25A, SCOTIN, RASSF1A and CACNA2D2 located in the chromosomal region 3p21.31 associated with the development of early dysplastic lesions of head and neck. In analysis of 72 dysplastic lesions and 116 squamous cell carcinoma of head and neck, both deletion and promoter methylation have been seen...
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