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Article

Improved A. faecalis penicillin amidase mutant retains the thermodynamic and pH stability of the wild type enzyme.

The protein journal - 1 Apr 2010

Yuryev Ruslan, Kasche Volker, Ignatova Zoya, Galunsky Boris

Abstract excerpt

Penicillin amidase from Alacaligenes faecalis is an attractive biocatalyst for hydrolysis of penicillin G for production of 6-aminopenicillanic acid, which is used in the synthesis of semi-synthetic beta-lactam antibiotics. Recently a mutant of this enzyme with extended C-terminus of the A-chain comprising parts of the connecting linker peptide was constructed. Its turnover number for the hydrolysis of penicillin...

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Identifiers

PMID: 20224955
DOI: 10.1007/s10930-010-9238-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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