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Article

Maximal entropy inference of oncogenicity from phosphorylation signaling.

Proceedings of the National Academy of Sciences of the United States of America - 30 Mar 2010

Graeber T G, Heath J R, Skaggs B J, Phelps M E, Remacle F, Levine R D

Abstract excerpt

Point mutations in the phosphorylation domain of the Bcr-Abl fusion oncogene give rise to drug resistance in chronic myelogenous leukemia patients. These mutations alter kinase-mediated signaling function and phenotypic outcome. An information theoretic analysis of the correlation of phosphoproteomic profiling and transformation potency of the oncogene in different mutants is presented. The theory seeks to...

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Identifiers

PMID: 20224037
DOI: 10.1073/pnas.1001149107
PMCID: PMC2851899

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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