Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased entropy of signal transduction in the cancer metastasis phenotype.

BMC systems biology - 30 Jul 2010

Teschendorff Andrew E, Severini Simone

Abstract excerpt

BACKGROUND: The statistical study of biological networks has led to important novel biological insights, such as the presence of hubs and hierarchical modularity. There is also a growing interest in studying the statistical properties of networks in the context of cancer genomics. However, relatively little is known as to what network features differ between the cancer and normal cell physiologies, or between...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Computational Biology
Share to Disease Progression
Share to Entropy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Regulatory Networks

Share to Neoplasm Metastasis

Share to Proteins

Share to Reproducibility of Results

Share to Stochastic Processes

Source

Open in PubMed Open full text

Identifiers

PMID: 20673354
DOI: 10.1186/1752-0509-4-104
PMCID: PMC2925356

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased entropy of signal transduction in the cancer metastasis phenotype.PMID 20673354Read ↗

Perturbation-Driven Entropy as a Source of Cancer Cell Heterogeneity.Semantic proximity Read ↗

Transcriptomic entropy reveals tissue-specific patterns in aging and predicts cancer progressionSemantic proximity Read ↗

A Theoretical Framework for Quantifying Tumour Resistance to Standardized Treatments: A Novel Rudimentary Scalar Mathematical Model with Implications for Breast Cancer Prognosis and TreatmentSemantic proximity Read ↗

Measuring intratumor heterogeneity by network entropy using RNA-seq dataSemantic proximity Read ↗

Local and global features of genetic networks supporting a phenotypic switch.Semantic proximity Read ↗

Intra-Tumour Signalling Entropy Determines Clinical Outcome in Breast and Lung CancerSemantic proximity Read ↗

Between-tumor and within-tumor heterogeneity in invasive potentialSemantic proximity Read ↗

Fisher Information Limits on Genetic Stability, Diversity, and Regulation.Semantic proximity Read ↗

Differential Shannon entropy and differential coefficient of variation: alternatives and augmentations to differential expression in the search for disease-related genes.Semantic proximity Read ↗

Frailness and resilience of gene networks predicted by detection of co-occurring mutations via a stochastic perturbative approach.Semantic proximity Read ↗

Maximal entropy inference of oncogenicity from phosphorylation signaling.Semantic proximity Read ↗

Surprisal analysis of transcripts expression levels in the presence of noise: a reliable determination of the onset of a tumor phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.