Article
An argument for mechanism-based statistical inference in cancer.
Human genetics - 1 May 2015
Geman Donald, Ochs Michael, Price Nathan D, Tomasetti Cristian, Younes Laurent
Abstract excerpt
Cancer is perhaps the prototypical systems disease, and as such has been the focus of extensive study in quantitative systems biology. However, translating these programs into personalized clinical care remains elusive and incomplete. In this perspective, we argue that realizing this agenda—in particular, predicting disease phenotypes, progression and treatment response for individuals—requires going well beyond...
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