Article
Variants of the Matrix Metalloproteinase-2 but not the Matrix Metalloproteinase-9 genes significantly influence functional outcome after stroke.
BMC medical genetics - 11 Mar 2010
Manso Helena, Krug Tiago, Sobral João, Albergaria Isabel, Gaspar Gisela, Ferro José M, Oliveira Sofia A, Vicente Astrid M
Abstract excerpt
BACKGROUND: Multiple lines of evidence suggest that genetic factors contribute to stroke recovery. The matrix metalloproteinases -2 (MMP-2) and -9 (MMP-9) are modulators of extracellular matrix components, with important regulatory functions in the Central Nervous System (CNS). Shortly after stroke, MMP-2 and MMP-9 have mainly damaging effects for brain tissue. However, MMPs also have a beneficial activity in...
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