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Article

Methylation in the matrix metalloproteinase-2 gene is associated with cerebral ischemic stroke.

Journal of investigative medicine : the official publication of the American Federation for Clinical Research - 1 Apr 2017

Lin Hsiu-Fen, Hsi Edward, Huang Ling-Chun, Liao Yi-Chu, Juo Suh-Hang H, Lin Ruey-Tay

Abstract excerpt

Matrix metalloproteinase-2 (MMP-2) is involved in the pathophysiology of stroke. Previous studies have shown that MMP-2 activity is increased in stroke; however, evidence of epigenetic regulation of the MMP-2 in stroke is still limited. We examined methylation of the MMP-2 promoter in patients with ischemic stroke. This study included 298 patients with ischemic stroke and 258 age-matched and sex-matched controls....

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Source

Identifiers

PMID: 28193703
DOI: 10.1136/jim-2016-000277

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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