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Article

Lack of association between the leptin receptor gene (LEPR) Gln223Arg polymorphism and late-onset Alzheimer disease.

Alzheimer disease and associated disorders - 1 Jan 2000

Utsunomiya Kensuke, Shinkai Takahiro, Sakata Shinichi, Hwang Rudi, Yamada Kenji, Chen Hsin-I, Fukunaka Yuko, Ohmori Osamu, Nakamura Jun

Abstract excerpt

The principal hypothesis for pathogenesis of Alzheimer disease (AD) is the amyloid cascade hypothesis, which emphasizes an imbalance between production and clearance of beta-amyloid (Abeta) in the brain. Insulin has important effects on the regulation of the Abeta level in the brain, modulating both Abeta production and clearance. An optimal brain insulin level promotes Abeta clearance, which may play protective...

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Source

Identifiers

PMID: 20220325
DOI: 10.1097/WAD.0b013e3181b982dc

Genes

LEPR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Lack of association between the leptin receptor gene (LEPR) Gln223Arg polymorphism and late-onset Alzheimer disease.PMID 20220325Read ↗

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A Common Variant in the MC1R Gene (p.V92M) is associated with Alzheimer's Disease Risk.Semantic proximity Read ↗

Lack of association between the levels of the low-density lipoprotein receptor-related protein (LRP) and either Alzheimer dementia or LRP exon 3 genotype.Semantic proximity Read ↗

Association of LEPR Gln223Arg Polymorphism with Obstructive Sleep Apnea Syndrome: A Meta-Analysis.Semantic proximity Read ↗

Association of LEPR Gln223Arg polymorphism with T2DM: A meta-analysis.Semantic proximity Read ↗

Case-control study and meta-analysis of low density lipoprotein receptor-related protein gene exon 3 polymorphism in Alzheimer's disease.Semantic proximity Read ↗

Lack of Association Between SLC24A4 Polymorphism and Late-onset Alzheimer's Disease in Han Chinese.Semantic proximity Read ↗

Amyloid precursor protein gene (APP) variation in late-onset Alzheimer's disease.Semantic proximity Read ↗

No genetic association between the LRP receptor and sporadic or late-onset familial Alzheimer disease.Semantic proximity Read ↗

No association between low density lipoprotein receptor genetic variants and Alzheimer's disease risk.Semantic proximity Read ↗

Lack of association between LEPR Q223R polymorphisms and cancer susceptibility: evidence from a meta-analysis.Semantic proximity Read ↗

Polymorphisms of insulin degrading enzyme gene are not associated with Alzheimer's disease.Semantic proximity Read ↗

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