Article
Base excision repair pathway genes polymorphism in prostate and bladder cancer risk in North Indian population.
Mechanisms of ageing and development - 1 Apr 2012
Mittal Rama Devi, Mandal Raju Kumar, Gangwar Ruchika
Abstract excerpt
PURPOSE: Carcinogens causes DNA damage, including oxidative lesions that are removed efficiently by the base excision repair (BER) pathway. Variations in BER genes may reduce DNA repair capacity, leading to development of urological cancers. METHODS: This study included 195 prostate cancer (PCa) and 212 bladder cancer (BC) patients and 250 controls who had been frequency matched by age, sex, and ethnicity. We...
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