Article
A screen for endocytic motifs.
Traffic (Copenhagen, Denmark) - 1 Jun 2010
Kozik Patrycja, Francis Richard W, Seaman Matthew N J, Robinson Margaret S
Abstract excerpt
Sorting signals for cargo selection into coated vesicles are usually in the form of short linear motifs. Three motifs for clathrin-mediated endocytosis have been identified: YXXPhi, [D/E]XXXL[L/I] and FXNPXY. To search for new endocytic motifs, we made a library of CD8 chimeras with random sequences in their cytoplasmic tails, and used a novel fluorescence-activated cell sorting (FACS)-based assay to select for...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
