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Article

Hypermutability of genes in Homo sapiens due to the hosting of long mono-SSR.

Molecular biology and evolution - 1 Jan 2009

Loire Etienne, Praz Françoise, Higuet Dominique, Netter Pierre, Achaz Guillaume

Abstract excerpt

Simple sequence repeats (SSRs) are very common short repeats in eukaryotic genomes. "Long" SSRs are considered "hypermutable" sequences because they exhibit a high rate of expansion and contraction. Because they are potentially deleterious, long SSRs tend to be uncommon in coding sequences. However, several genes contain long SSRs in their exonic sequences. Here, we identify 1,291 human genes that host a...

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PMID: 18845548
DOI: 10.1093/molbev/msn230

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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