Article
Polymorphisms in the Pseudomonas aeruginosa type III secretion protein, PcrV - implications for anti-PcrV immunotherapy.
Microbial pathogenesis - 1 Jun 2010
Lynch Susan V, Flanagan Judith L, Sawa Teiji, Fang Alice, Baek Marshall S, Rubio-Mills Amua, Ajayi Temitayo, Yanagihara Katsunori, Hirakata Yoichi, Kohno Shigeru, Misset Benoit, Nguyen Jean-Claude, Wiener-Kronish Jeanine P
Abstract excerpt
The type III secretion system of Pseudomonas aeruginosa, responsible for acute infection, is composed of over twenty proteins that facilitate cytotoxin injection directly into host cells. Integral to this process is production and secretion of PcrV. Administration of a recently developed, anti-PcrV immunoglobulin, either as a therapeutic or prophylactic has previously demonstrated efficacy against laboratory...
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