Prognostic impact of ZAP-70 expression in chronic lymphocytic leukemia: mean fluorescence intensity T/B ratio versus percentage of positive cells.

doi:10.1186/1479-5876-8-23

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Article

Prognostic impact of ZAP-70 expression in chronic lymphocytic leukemia: mean fluorescence intensity T/B ratio versus percentage of positive cells.

Journal of translational medicine - 8 Mar 2010

Rossi Francesca M, Del Principe Maria Ilaria, Rossi Davide, Irno Consalvo Maria, Luciano Fabrizio, Zucchetto Antonella, Bulian Pietro, Bomben Riccardo, Dal Bo Michele, Fangazio Marco, Benedetti Dania, Degan Massimo, Gaidano Gianluca, Del Poeta Giovanni, Gattei Valter

Abstract excerpt

BACKGROUND: ZAP-70 is an independent negative prognostic marker in chronic lymphocytic leukemia (CLL). Usually, its expression is investigated by flow cytometric protocols in which the percentage of ZAP-70 positive CLL cells is determined in respect to isotypic control (ISO-method) or residual ZAP-70 positive T cells (T-method). These methods, however, beside suffering of an inherent subjectivity in their...

Topics

Adult
Aged
Aged, 80 and over
B-Lymphocytes
Biomarkers, Tumor
Female
Flow Cytometry
Humans
Immunoglobulin Heavy Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Kaplan-Meier Estimate

Leukemia, Lymphocytic, Chronic, B-Cell

Lymphocyte Subsets

Male

Middle Aged

Multivariate Analysis

Mutation

Prognosis

Reproducibility of Results

Source

Open in PubMed Open full text

Identifiers

PMID: 20211015
DOI: 10.1186/1479-5876-8-23
PMCID: PMC2846891

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