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Article

Characterization of the Human Cytochrome P4502D6 Promoter

1 Oct 1996

Abstract excerpt

The functional mapping of the human cytochrome P4502D6 (CYP2D6) promoter in HepG2 cells revealed the presence of both positive and negative regulatory elements. One of these regulatory elements overlapped a sequence that is highly conserved in most members of the CYP2 family. This element, which consists of a degenerate AGGTCA direct repeat spaced by 1 base pair (DR1) and is known to be a target for members of...

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Identifiers

PMID: 8810289
DOI: 10.1074/jbc.271.41.25269

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