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Article

GATA-4 transcription factor regulates hepatic hepcidin expression.

The Biochemical journal - 1 Aug 2011

Island Marie-Laure, Fatih Nadia, Leroyer Patricia, Brissot Pierre, Loreal Olivier

Abstract excerpt

Hepcidin, a hormone mainly synthesized by hepatocytes and secreted in plasma, controls iron bioavailability. Thus, by inducing the internalization of the iron exporter ferroportin, it regulates iron release from macrophages, enterocytes and hepatocytes towards plasma. Abnormal levels of hepcidin...

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Source

Identifiers

PMID: 21609320
DOI: 10.1042/BJ20110225

Genes

GATA4
HAMP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21609320-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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GATA-4 transcription factor regulates hepatic hepcidin expression.PMID 21609320Read ↗

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The transcription factor GATA-4 regulates cytochrome P4502C19 gene expression.Semantic proximity Read ↗

Hepcidin, a key regulator of iron metabolism, is transcriptionally activated by p53.Semantic proximity Read ↗

Hepcidin, the recently identified peptide that appears to regulate iron absorption.Semantic proximity Read ↗

The regulation of hepcidin expression by serum treatment: requirements of the BMP response element and STAT- and AP-1-binding sites.Semantic proximity Read ↗

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