Article
A sequence dimorphism in a conserved domain of human 28S rRNA. Uneven distribution of variant genes among individuals. Differential expression in HeLa cells.
Nucleic acids research - 11 Mar 1991
Qu L H, Nicoloso M, Bachellerie J P
Abstract excerpt
In humans, cellular 28S rRNA displays a sequence dimorphism within an evolutionarily conserved motif, with the presence, at position +60, of either a A (like the metazoan consensus) or a G. The relative abundance of the two forms of variant genes in the genome exhibit large differences among individuals. The two variant forms are generally represented in cellular 28S rRNA in proportion of their relative abundance...
Topics
- Base Sequence
- Biological Evolution
- Blotting, Southern
- Cell Line
- DNA
- Gene Expression
- Genetic Variation
- HeLa Cells
- Humans
- Molecular Sequence Data
- Nucleic Acid Conformation