Article
Impacts of ribosomal RNA sequence variation on gene expression and phenotype.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 6 Mar 2025
Welfer Griffin A, Brady Ryan A, Natchiar S Kundhavai, Watson Zoe L, Rundlet Emily J, Alejo Jose L, Singh Anand P, Mishra Nitish K, Altman Roger B, Blanchard Scott C
Abstract excerpt
Since the framing of the Central Dogma, it has been speculated that physically distinct ribosomes within cells may influence gene expression and cellular physiology. While heterogeneity in ribosome composition has been reported in bacteria, protozoans, fungi, zebrafish, mice and humans, its functional implications remain actively debated. Here, we review recent evidence demonstrating that expression of conserved...
Topics
- Animals
- Humans
- RNA, Ribosomal
- Phenotype
- Ribosomes
- Mice
- Genetic Variation
- Gene Expression
- Escherichia coli