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Article

The evolutionarily conserved interaction between LC3 and p62 selectively mediates autophagy-dependent degradation of mutant huntingtin.

Cellular and molecular neurobiology - 1 Jul 2010

Tung Ying-Tsen, Hsu Wen-Ming, Lee Hsinyu, Huang Wei-Pang, Liao Yung-Feng

Abstract excerpt

Mammalian p62/sequestosome-1 protein binds to both LC3, the mammalian homologue of yeast Atg8, and polyubiquitinated cargo proteins destined to undergo autophagy-mediated degradation. We previously identified a cargo receptor-binding domain in Atg8 that is essential for its interaction with the c...

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PMID: 20204693
DOI: 10.1007/s10571-010-9507-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20204693-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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