Article
Functions of base selection step in human DNA polymerase alpha.
DNA repair - 4 May 2010
Tanaka Shigeru, Cao Ke, Niimi Atsuko, Limsirichaikul Siripan, Miao Huang Qin, Nakamura Noriko, Murate Takashi, Hasegawa Yoshinori, Takahashi Takashi, Suzuki Motoshi
Abstract excerpt
Recent studies have revealed that the base selection step of DNA polymerases (pol) plays a role in prevention of DNA replication errors. We investigated whether base selection is required for the DNA replication fidelity of pol alpha and genomic stability in human cells. We introduced an Leu864 t...
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