Article
Leucine-rich repeat kinase 2 gene-associated disease: redefining genotype-phenotype correlation.
Neuro-degenerative diseases - 1 Jan 2010
Wider Christian, Dickson Dennis W, Wszolek Zbigniew K
Abstract excerpt
BACKGROUND: Leucine-rich repeat kinase 2 (LRRK2) has emerged as the most prevalent genetic cause of Parkinson's disease (PD) among Caucasians. Patients carrying an LRRK2 mutation display significant variability of clinical and pathologic phenotypes across and within affected families. METHODS: Herein, we review available clinical and pathologic data on patients with an LRRK2 mutation who have come to autopsy....
Topics
- Adult
- Aged
- Aged, 80 and over
- DNA-Binding Proteins
- Family Health
- Female
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Genotype
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2