Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The cytoplasmic NPM mutant induces myeloproliferation in a transgenic mouse model.

Blood - 22 Apr 2010

Cheng Ke, Sportoletti Paolo, Ito Keisuke, Clohessy John G, Teruya-Feldstein Julie, Kutok Jeffery L, Pandolfi Pier Paolo

Abstract excerpt

Although NPM1 gene mutations leading to aberrant cytoplasmic expression of nucleophosmin (NPMc(+)) are the most frequent genetic lesions in acute myeloid leukemia, there is yet no experimental model demonstrating their oncogenicity in vivo. We report the generation and characterization of a transgenic mouse model expressing the most frequent human NPMc(+) mutation driven by the myeloid-specific human MRP8...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Separation
Share to Cytoplasm
Share to Flow Cytometry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Leukemic

Share to Leukemia, Myeloid, Acute

Share to Mice, Inbred CBA

Share to Myeloid Cells

Share to Nucleophosmin

Source

Open in PubMed Open full text

Identifiers

PMID: 19666870
DOI: 10.1182/blood-2009-03-208587
PMCID: PMC2858489

Genes

NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The cytoplasmic NPM mutant induces myeloproliferation in a transgenic mouse model.PMID 19666870Read ↗

Expression of the cytoplasmic NPM1 mutant (NPMc+) causes the expansion of hematopoietic cells in zebrafish.Semantic proximity Read ↗

A knock-in Npm1 mutation in mice results in myeloproliferation and implies a perturbation in hematopoietic microenvironment.Semantic proximity Read ↗

Cytoplasmic mutated nucleophosmin is stable in primary leukemic cells and in a xenotransplant model of NPMc+ acute myeloid leukemia in SCID mice.Semantic proximity Read ↗

Mutant nucleophosmin deregulates cell death and myeloid differentiation through excessive caspase-6 and -8 inhibition.Semantic proximity Read ↗

Mouse models of NPM1-mutated acute myeloid leukemia: biological and clinical implications.Semantic proximity Read ↗

Npm1 is a haploinsufficient suppressor of myeloid and lymphoid malignancies in the mouse.Semantic proximity Read ↗

Altered nucleophosmin transport in acute myeloid leukaemia with mutated NPM1: molecular basis and clinical implications.Semantic proximity Read ↗

Acute myeloid leukemia carrying cytoplasmic/mutated nucleophosmin (NPMc+ AML): biologic and clinical features.Semantic proximity Read ↗

Cytoplasmic mutated nucleophosmin (NPM) defines the molecular status of a significant fraction of myeloid sarcomasSemantic proximity Read ↗

Overview of Transgenic Mouse Models of Myeloproliferative Neoplasms (MPNs).Semantic proximity Read ↗

Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice.Semantic proximity Read ↗

NPMc+ cooperates with Flt3/ITD mutations to cause acute leukemia recapitulating human disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.