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Transduction of wild-type merlin into human schwannoma cells decreases schwannoma cell growth and induces apoptosis

1 Jan 2002

Abstract excerpt

Mutations in both alleles of the tumour suppressor gene coding for merlin/schwannomin, an ERM family protein, cause the hereditary disease neurofibromatosis type 2 (NF2). NF2 is characterized by the development of multiple nervous system tumours especially vestibular schwannomas. Efficient oncoretrovirus-mediated gene transfer of different merlin constructs was used to stably re-express wild-type merlin in...

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PMID: 11773000
DOI: 10.1093/hmg/11.1.69

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