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Article

The scaffold protein TANK/I-TRAF inhibits NF-kappaB activation by recruiting polo-like kinase 1.

Molecular biology of the cell - 15 Jul 2010

Zhang Wanqiao, Wang Jian, Zhang Ying, Yuan Yanzhi, Guan Wei, Jin Chaozhi, Chen Hui, Wang Xiaohui, Yang Xiaoming, He Fuchu

Abstract excerpt

TANK/I-TRAF is a TRAF-binding protein that negatively regulates NF-kappaB activation. The underlying mechanism of this activity remains unclear. Here we show that TANK directly interacts with PLK1, a conserved cell cycle-regulated kinase. PLK1 inhibits NF-kappaB transcriptional activation induced...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20484576
DOI: 10.1091/mbc.e09-08-0715
PMCID: PMC2903677

Genes

PLK1
TANK
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20484576-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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