Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PTH battles TGF-beta in bone.

Nature cell biology - 1 Mar 2010

Atfi Azeddine, Baron Roland

Abstract excerpt

Bone remodelling in vertebrates is coordinately regulated by the opposing effects of parathyroid hormone (PTH) and transforming growth factor-beta (TGF-beta). PTH couples the processes of bone resorption and formation by enforcing simultaneous internalization of TGF-beta type II receptor (TbetaRII) and PTH type 1 receptor (PTH1R), which attenuates both TGF-beta and PTH signalling in vivo.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Parathyroid Hormone
Share to Receptor, Parathyroid Hormone, Type 1
Share to Osteoclasts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bone Remodeling

Share to Cyclic AMP Response Element-Binding Protein

Share to Receptor, Transforming Growth Factor-beta Type II

Share to Receptors, Transforming Growth Factor beta

Share to Smad Proteins

Source

Identifiers

PMID: 20190828
DOI: 10.1038/ncb0310-205

Genes

PTH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PTH battles TGF-beta in bone.PMID 20190828Read ↗

TGF-beta type II receptor phosphorylates PTH receptor to integrate bone remodelling signalling.Semantic proximity Read ↗

The roles and regulatory mechanisms of TGF-β and BMP signaling in bone and cartilage development, homeostasis and diseaseSemantic proximity Read ↗

Transforming growth factor-beta1 to the bone.Semantic proximity Read ↗

T cells: Critical bone regulators in health and diseaseSemantic proximity Read ↗

Talking among Ourselves: Paracrine Control of Bone Formation within the Osteoblast LineageSemantic proximity Read ↗

Parathyroid Hormone Directs Bone Marrow Mesenchymal Cell Fate.Semantic proximity Read ↗

Disruption of BMP Signaling Prevents Hyperthyroidism-Induced Bone Loss in Male MiceSemantic proximity Read ↗

Activated parathyroid hormone/parathyroid hormone-related protein receptor in osteoblastic cells differentially affects cortical and trabecular bone.Semantic proximity Read ↗

Osteoblastic responses to TGF-beta during bone remodeling.Semantic proximity Read ↗

Endogenous ligand recognition and structural transition of a human PTH receptorSemantic proximity Read ↗

The skeletal phenotypes of TRalpha and TRbeta mutant mice.Semantic proximity Read ↗

IGF-I receptor is required for the anabolic actions of parathyroid hormone on bone.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.