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Article

Parathyroid Hormone Directs Bone Marrow Mesenchymal Cell Fate.

Cell metabolism - 7 Mar 2017

Fan Yi, Hanai Jun-Ichi, Le Phuong T, Bi Ruiye, Maridas David, DeMambro Victoria, Figueroa Carolina A, Kir Serkan, Zhou Xuedong, Mannstadt Michael, Baron Roland, Bronson Roderick T, Horowitz Mark C, Wu Joy Y, Bilezikian John P, Dempster David W, Rosen Clifford J, Lanske Beate

Abstract excerpt

Intermittent PTH administration builds bone mass and prevents fractures, but its mechanism of action is unclear. We genetically deleted the PTH/PTHrP receptor (PTH1R) in mesenchymal stem cells using Prx1Cre and found low bone formation, increased bone resorption, and high bone marrow adipose tissue (BMAT). Bone marrow adipocytes traced to Prx1 and expressed classic adipogenic markers and high receptor activator...

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Source

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Identifiers

PMID: 28162969
DOI: 10.1016/j.cmet.2017.01.001
PMCID: PMC5342925

Genes

PTH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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