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Article

Inhibition of mammary carcinoma cell growth by RXR is mediated by the receptor's oligomeric switch.

Journal of molecular biology - 16 Apr 2010

Yasmin Rubina, Kannan-Thulasiraman Padmamalini, Kagechika Hiroyuki, Dawson Marcia I, Noy Noa

Abstract excerpt

Ligands that activate the nuclear receptor retinoid X receptor (RXR) display potent anticarcinogenic activities, but the mechanisms by which these compounds inhibit carcinoma cell growth are poorly understood. While RXR can regulate gene expression due to its intrinsic ligand-activated transcription function, this receptor can also regulate transcription by functioning as a ligand-controlled DNA architectural...

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Identifiers

PMID: 20188110
DOI: 10.1016/j.jmb.2010.02.030
PMCID: PMC2847374

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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