Article
Role of ligand in retinoid signaling. 9-cis-retinoic acid modulates the oligomeric state of the retinoid X receptor.
Biochemistry - 24 Oct 1995
Kersten S, Pan L, Chambon P, Gronemeyer H, Noy N
Abstract excerpt
Many of the effects of retinoids on cells are mediated by the transcription factors known as retinoid nuclear receptors, but the mechanisms by which retinoids regulate the activity of the receptors are not known. It was previously shown that the retinoid X receptor (RXR) forms tetramers with a high affinity. In the present work it is demonstrated that binding of 9-cis-retinoic acid to RXR leads to rapid...
Topics
- Binding Sites
- DNA
- Electrophoresis, Polyacrylamide Gel
- Fluorescence Polarization
- Ligands
- Mutation
- Nuclear Proteins
- Protein Binding
- Protein Conformation
- Receptors, Retinoic Acid
- Recombinant Proteins