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Article

Targeting A20 decreases glioma stem cell survival and tumor growth.

PLoS biology - 23 Feb 2010

Hjelmeland Anita B, Wu Qiulian, Wickman Sarah, Eyler Christine, Heddleston John, Shi Qing, Lathia Justin D, Macswords Jennifer, Lee Jeongwu, McLendon Roger E, Rich Jeremy N

Abstract excerpt

Glioblastomas are deadly cancers that display a functional cellular hierarchy maintained by self-renewing glioblastoma stem cells (GSCs). GSCs are regulated by molecular pathways distinct from the bulk tumor that may be useful therapeutic targets. We determined that A20 (TNFAIP3), a regulator of...

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Source

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Identifiers

PMID: 20186265
DOI: 10.1371/journal.pbio.1000319
PMCID: PMC2826371

Genes

GSC
TNFAIP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20186265-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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