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Article

A CDC20-APC/SOX2 Signaling Axis Regulates Human Glioblastoma Stem-like Cells

1 Jun 2015

Abstract excerpt

Glioblastoma harbors a dynamic subpopulation of glioblastoma stem-like cells (GSCs) that can propagate tumors in vivo and is resistant to standard chemoradiation. Identification of the cell-intrinsic mechanisms governing this clinically important cell state may lead to the discovery of therapeutic strategies for this challenging malignancy. Here, we demonstrate that the mitotic E3 ubiquitin ligase...

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PMID: 26074073
DOI: 10.1016/j.celrep.2015.05.027

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