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Article

Genetic predisposition to advanced glycation end products toxicity is related to prognosis of chronic hemodialysis patients.

Kidney & blood pressure research - 1 Jan 2010

Kalousová Marta, Jáchymová Marie, Germanová Alexandra, Kubena Ales Antonín, Tesar Vladimír, Zima Tomás

Abstract excerpt

BACKGROUND: Advanced glycation end products (AGEs) belong to uremic toxins and some pathological effects of AGEs are linked to RAGE (receptor for AGEs). Their precursors are detoxified by the glyoxalase (GLO) system. The A419C (E111A) polymorphism of the GLO I gene is associated with vascular disease in hemodialysis (HD) patients and some RAGE gene polymorphisms are implicated in various pathological states. AIM:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20185929
DOI: 10.1159/000285845

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