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Article

Contrasting association of a non-synonymous leptin receptor gene polymorphism with Wegener's granulomatosis and Churg-Strauss syndrome.

Rheumatology (Oxford, England) - 1 May 2010

Wieczorek Stefan, Holle Julia U, Bremer Jan P, Wibisono David, Moosig Frank, Fricke Harald, Assmann Gunter, Harper Lorraine, Arning Larissa, Gross Wolfgang L, Epplen Joerg T

Abstract excerpt

OBJECTIVE: There is evidence that the leptin/ghrelin system is involved in T-cell regulation and plays a role in (auto)immune disorders such as SLE, RA and ANCA-associated vasculitides (AAVs). Here, we evaluate the genetic background of this system in WG. METHODS: We screened variations in the genes encoding leptin, ghrelin and their receptors, the leptin receptor (LEPR) and the growth hormone secretagogue...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20185531
DOI: 10.1093/rheumatology/kep420

Genes

LEPR
GHSR

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