Article
Association of FCGR2A and FCGR2A-FCGR3A haplotypes with susceptibility to giant cell arteritis.
Arthritis research & therapy - 1 Jan 2006
Morgan Ann W, Robinson Jim I, Barrett Jennifer H, Martin Javier, Walker Amy, Babbage Sarah J, Ollier William E R, Gonzalez-Gay Miguel A, Isaacs John D
Abstract excerpt
The Fc gamma receptors have been shown to play important roles in the initiation and regulation of many immunological and inflammatory processes and to amplify and refine the immune response to an infection. We have investigated the hypothesis that polymorphism within the FCGR genetic locus is associated with giant cell arteritis (GCA). Biallelic polymorphisms in FCGR2A, FCGR3A, FCGR3B and FCGR2B were examined...
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