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Article

Expression of Toll-like receptor 9 in renal podocytes in childhood-onset active and inactive lupus nephritis

24 Feb 2010

Abstract excerpt

BACKGROUND: Childhood-onset systemic lupus erythematosus (SLE) is frequently complicated with lupus nephritis (LN), which is characterized by the deposition of DNA-containing immune complex to the glomerulus. Toll-like receptor 9 (TLR9), capable of recognizing the microbially derived CpG oligonucleotide, plays a crucial role in the innate immunity. TLR9 is also assumed to be related to the aetiology of SLE in the...

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PMID: 20181802
DOI: 10.1093/ndt/gfq058

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