Article
Temporal regulation of a paired-like homeodomain repressor/TLE corepressor complex and a related activator is required for pituitary organogenesis.
Genes & development - 1 Dec 2001
Dasen J S, Martinez Barbera J P, Herman T S, Connell S O, Olson L, Ju B, Tollkuhn J, Baek S H, Rose D W, Rosenfeld M G
Abstract excerpt
Understanding the functional significance of the coordinate expression of specific corepressors and DNA-binding transcription factors remains a critical question in mammalian development. During the development of the pituitary gland, two highly related paired-like homeodomain factors, a repressor, Hesx1/Rpx and an activator, Prop-1, are expressed in sequential, overlapping temporal patterns. Here we show that...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.