Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Frequent transcriptional inactivation of Kallikrein 10 gene by CpG island hypermethylation in non‐small cell lung cancer

28 Dec 2009

Abstract excerpt

The role of Kallikrein 10 gene (KLK10) in non-small cell lung cancer (NSCLC) remains largely unknown. We determined the frequency and functional significance of KLK10 hypermethylation in NSCLC. The mRNA expression and methylation status of KLK10 in 78 pairs NSCLC specimens was explored. The biological effects of KLK10 were analyzed by transfection. The results showed that, KLK10 was significantly downregulated in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related gene regulation
Share to Coagulation, Bradykinin, Polyphosphates, and Angioedema
Share to Kruppel-like factors research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20180809
DOI: 10.1111/j.1349-7006.2009.01486.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Frequent transcriptional inactivation of Kallikrein 10 gene by CpG island hypermethylation in non‐small cell lung cancerPMID 20180809Read ↗

KLK5 and KLK7, two members of the human tissue kallikrein family, are differentially expressed in lung cancerSemantic proximity Read ↗

Protocadherin 10 is frequently downregulated by promoter methylation and functions as a tumor suppressor gene in non-small cell lung cancerSemantic proximity Read ↗

Kallikrein-related peptidases in lung diseasesSemantic proximity Read ↗

STK11/LKB1 Loss of Function Is Associated with Global DNA Hypomethylation and S-Adenosyl-Methionine Depletion in Human Lung Adenocarcinoma.Semantic proximity Read ↗

<i>NAA10</i> Hypomethylation is associated with particulate matter exposure and worse prognosis for patients with non-small cell lung cancerSemantic proximity Read ↗

Identification of new splice variants and differential expression of the human kallikrein 10 gene, a candidate cancer biomarker.Semantic proximity Read ↗

Long‑term exposure to gefitinib induces acquired resistance through DNA methylation changes in the EGFR‑mutant PC9 lung cancer cell line.Semantic proximity Read ↗

miR-101 DNA copy loss is a prominent subtype specific event in lung cancer.Semantic proximity Read ↗

Identification of single nucleotide polymorphisms in the human kallikrein 10 (KLK10) gene and their association with prostate, breast, testicular, and ovarian cancers.Semantic proximity Read ↗

Three dysregulated miRNAs control kallikrein 10 expression and cell proliferation in ovarian cancerSemantic proximity Read ↗

Epigenetic identification of mitogen-activated protein kinase 10 as a functional tumor suppressor and clinical significance for hepatocellular carcinomaSemantic proximity Read ↗

Kallikrein 10 (KLK10) methylation as a novel prognostic biomarker in early breast cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.