Article
Three dysregulated miRNAs control kallikrein 10 expression and cell proliferation in ovarian cancer
30 Mar 2010
Abstract excerpt
BACKGROUND: Kallikrein-related peptidases (KLKs) are a family of serine proteases that have been shown to be dysregulated in several malignancies including ovarian cancer. The control of kallikrein genes and their physiological function in cancer is not well understood. We hypothesized that microRNAs (miRNAs) represent a novel mechanism for post-transcriptional control of KLK expression in cancer. METHODS: We...
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