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Article

Long‑term exposure to gefitinib induces acquired resistance through DNA methylation changes in the EGFR‑mutant PC9 lung cancer cell line.

International journal of oncology - 1 Jan 2015

Terai Hideki, Soejima Kenzo, Yasuda Hiroyuki, Sato Takashi, Naoki Katsuhiko, Ikemura Shinnosuke, Arai Daisuke, Ohgino Keiko, Ishioka Kota, Hamamoto Junko, Kanai Yae, Betsuyaku Tomoko

Abstract excerpt

This study was designed to identify epigenetically regulated genes and to clarify the contribution of epige-netic alteration to acquired resistance to epidermal growth factor receptor‑tyrosine kinase inhibitors (EGFR‑TKIs). We established a gefitinib‑resistant lung cancer cell line, PC9, which was originally gefitinib‑sensitive, by serial long‑term exposure to gefitinib. RNA and DNA were collected from both...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25353970
DOI: 10.3892/ijo.2014.2733

Genes

EGFR
IGFBP3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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