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Article

The interaction between tBid and cardiolipin or monolysocardiolipin.

Biochemical and biophysical research communications - 13 May 2005

Liu Jihua, Durrant David, Yang Hung-Sheng, He Yongwen, Whitby Francis G, Myszka David G, Lee Ray M

Abstract excerpt

Bid, a BH3-only pro-apoptotic member of the Bcl-2 family, is cleaved by caspase 8 in apoptosis induced by death domain receptors. The carboxyl terminus of the cleavage product, tBid, remains associated with the amino terminal fragment (nBid) after cleavage. Dissociation of tBid from nBid occurs during targeting of tBid to mitochondria. We use an in vitro system and demonstrate that cardiolipin is sufficient for...

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Identifiers

PMID: 15809076
DOI: 10.1016/j.bbrc.2005.03.048

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The interaction between tBid and cardiolipin or monolysocardiolipin.PMID 15809076Read ↗

Mechanistic issues of the interaction of the hairpin-forming domain of tBid with mitochondrial cardiolipin.Semantic proximity Read ↗

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tBid elicits a conformational alteration in membrane-bound Bcl-2 such that it inhibits Bax pore formation.Semantic proximity Read ↗

A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis.Semantic proximity Read ↗

Permeabilization of the mitochondrial outer membrane by Bax/truncated Bid (tBid) proteins as sensitized by cardiolipin hydroperoxide translocation: mechanistic implications for the intrinsic pathway of oxidative apoptosis.Semantic proximity Read ↗

tBid undergoes multiple conformational changes at the membrane required for Bax activation.Semantic proximity Read ↗

Bid binding to negatively charged phospholipids may not be required for its pro-apoptotic activity in vivo.Semantic proximity Read ↗

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Leakage and aggregation of phospholipid vesicles induced by the BH3-only Bcl-2 family member, BID.Semantic proximity Read ↗

Oligomerization of membrane-bound Bcl-2 is involved in its pore formation induced by tBid.Semantic proximity Read ↗

Transmembrane pore formation by the carboxyl terminus of Bax protein.Semantic proximity Read ↗

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