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Article

A novel humanized mouse lacking murine P450 oxidoreductase for studying human drug metabolism.

Nature communications - 28 Jun 2017

Barzi Mercedes, Pankowicz Francis P, Zorman Barry, Liu Xing, Legras Xavier, Yang Diane, Borowiak Malgorzata, Bissig-Choisat Beatrice, Sumazin Pavel, Li Feng, Bissig Karl-Dimiter

Abstract excerpt

Only one out of 10 drugs in development passes clinical trials. Many fail because experimental animal models poorly predict human xenobiotic metabolism. Human liver chimeric mice are a step forward in this regard, as the human hepatocytes in chimeric livers generate human metabolites, but the remaining murine hepatocytes contain an expanded set of P450 cytochromes that form the major class of drug-metabolizing...

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Identifiers

PMID: 28659616
DOI: 10.1038/s41467-017-00049-x
PMCID: PMC5489481

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