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Article

Experimental Variables that Affect Human Hepatocyte AAV Transduction in Liver Chimeric Mice

2 Jun 2020

Abstract excerpt

Adeno-associated virus (AAV) vector serotypes vary in their ability to transduce hepatocytes from different species. Chimeric mouse models harboring human hepatocytes have shown translational promise for liver-directed gene therapies. However, many variables that influence human hepatocyte transduction and transgene expression in such models remain poorly defined. Here, we aimed to test whether three experimental...

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PMID: 32637450
DOI: 10.1016/j.omtm.2020.05.033

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