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Article

Introduction of a leucine half-zipper engenders multiple high-quality crystals of a recalcitrant tRNA synthetase.

Acta crystallographica. Section D, Biological crystallography - 1 Mar 2010

Guo Min, Shapiro Ryan, Schimmel Paul, Yang Xiang-Lei

Abstract excerpt

Although Escherichia coli alanyl-tRNA synthetase was among the first tRNA synthetases to be sequenced and extensively studied by functional analysis, it has proved to be recalcitrant to crystallization. This challenge remained even for crystallization of the catalytic fragment. By mutationally in...

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Identifiers

PMID: 20179335
DOI: 10.1107/S0907444909055462
PMCID: PMC2827346

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20179335-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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